Online citations, reference lists, and bibliographies.
← Back to Search

Manual Contouring Based Volumetric Evaluation For Colorectal Cancer With Liver Limited Metastases: A Comparison With RECIST.

W. Fang, K. Lam, S. Ng, C. W. Choi, D. Kwong, S. S. Zheng, V. Lee
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
BACKGROUND To compare response evaluation criteria in solid tumours (RECIST) and volumetric evaluation (VE) for colorectal cancer with liver-limited metastasis. PATIENTS AND METHODS VE of liver metastases was performed by manual contouring before and after chemotherapy on 45 pairs of computed tomography (CT) images in 36 patients who suffered from metastatic colorectal cancer (mCRC) with liver metastasis only. Cohen kappa was used to compare the agreement between VE and RECIST. Pearson correlation was performed for their comparison after cubic root transformation of the aggregate tumor volumes. Logistic regression was done to identify clinical and radiographic factors to account for the difference which may be predictive in overall response (OR). RESULTS There were 16 partial response (PR), 23 stable disease (SD) and 6 progressive disease (PD) cases with VE, and 14 PR, 23 SD and 8 PD with RECIST. VE demonstrated good agreement with RECIST (κ=0.779). Discordant objective responses were noted in 6 pairs of comparisons (13.3%). Pearson correlation also showed excellent correlation between VE and RECIST (r2=0.966, p<0.001). Subgroup analysis showed that VE was in slightly better agreement with RECIST for enlarging lesions than for shrinking lesions (r2=0.935 and r2=0.780 respectively). No factor was found predictive of the difference in OR between VE and RECIST. CONCLUSIONS VE exhibited good agreement with RECIST. It might be more useful than RECIST in evaluation shrinking lesions in cases of numerous and conglomerate liver metastases.
This paper references
New guidelines to evaluate the response to treatment in solid tumors
P. Therasse (2000)
Living donor right liver lobes: preoperative CT volumetric measurement for calculation of intraoperative weight and volume.
A. Lemke (2006)
Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer.
J. Cassidy (2008)
[New response evaluation criteria in solid tumours-revised RECIST guideline (version 1.1)].
H. Watanabe (2009)
Measurement of Observer Agreement Measurement of Agreement of Two Readers
H. Kundel (2003)
CT assessment of tumour response to treatment: comparison of linear, cross-sectional and volumetric measures of tumour size.
S. Sohaib (2000)
Volumetric evaluation of liver metastases after thermal ablation: long-term results following MR-guided laser-induced thermotherapy.
T. Vogl (2008)
Survivin expression and targeting in breast cancer.
Kumkum Jha (2012)
Comparison of treatment response classifications between unidimensional, bidimensional, and volumetric measurements of metastatic lung lesions on chest computed tomography.
Lien Tran (2004)
CT tumor measurement for therapeutic response assessment: comparison of unidimensional, bidimensional, and volumetric techniques initial observations.
S. Prasad (2002)
Effect of varying CT section width on volumetric measurement of lung tumors and application of compensatory equations.
H. Winer-Muram (2003)
Small pulmonary nodules: volumetrically determined growth rates based on CT evaluation.
D. Yankelevitz (2000)
Modeling of mesothelioma growth demonstrates weaknesses of current response criteria.
G. Oxnard (2006)
Evaluation of hepatocellular carcinoma size using twodimensional and volumetric analysis: effect on liver transplantation
MS Galizia (2011)
Multidetector CT (64 Slices) of the liver: examination techniques
A. Laghi (2006)
Preoperative Liver Volumetry: How Does the Slice Thickness Influence the Multidetector Computed Tomography- and Magnetic Resonance-Liver Volume Measurements?
C. Reiner (2009)
Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?
M. Mantatzis (2009)
Volumetry: an alternative to assess therapy response for malignant pleural mesothelioma?
T. Frauenfelder (2011)
Evaluation of hepatocellular carcinoma size using two-dimensional and volumetric analysis: effect on liver transplantation eligibility.
M. Galizia (2011)
Therapy response in malignant pleural mesothelioma-role of MRI using RECIST, modified RECIST and volumetric approaches in comparison with CT
C. Plathow (2008)
Noncalcified lung nodules: volumetric assessment with thoracic CT.
M. Gavrielides (2009)
We should desist using RECIST, at least in GIST.
R. Benjamin (2007)
Implications of clinical risk score to predict outcomes of liver-confined metastasis of colorectal cancer.
S. Shin (2012)
Measurement of observer agreement.
H. Kundel (2003)
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.
C. Bokemeyer (2009)
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
E. Chiorean (2011)
[Follow-up CT measurement of liver malignoma according to RECIST and WHO vs. volumetry].
C. Heussel (2007)
Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
R. K. Pearson (2010)
The Lung Image Database Consortium (LIDC): a comparison of different size metrics for pulmonary nodule measurements.
A. Reeves (2007)
Computed Tomography RECIST Assessment of Histopathologic Response and Prediction of Survival in Patients with Resectable Non–Small-Cell Lung Cancer after Neoadjuvant Chemotherapy
W. William (2013)
Measurement of mesothelioma on thoracic CT scans: a comparison of manual and computer-assisted techniques.
S. Armato (2004)
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.
A. de Gramont (2000)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar