Online citations, reference lists, and bibliographies.
← Back to Search

Risk Factors For Doxorubicin-induced Congestive Heart Failure.

D. V. Von Hoff, M. Layard, P. Basa, H. L. Davis, A. L. Von Hoff, M. Rozencweig, F. Muggia
Published 1979 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Potential risk factors responsible for development of doxorubicin-induced congestive heart failure were examined through retrospective analysis of 4018 patient records. The overall incidence of drug-induced congestive heart failure was 2.2% (88 cases). The probability of incurring doxorubicin-induced congestive heart failure was related to the total dose of doxorubicin administered. There was a continuum of increasing risk as the cumulative amount of administered drug increased. A weekly dose schedule of doxorubicin was associated with a significantly lower incidence of congestive heart failure than was the usually employed every 3-week schedule. An increase in drug-related congestive heart failure was also seen with advancing patient age. Performance status, sex, race, and tumor type were not risk factors. These data will enable clinicians to better estimate the risk/benefit ratio in individual patients receiving prolonged administration of doxorubicin. They also provide a basis for the investigation of less cardiotoxic anthracycline analogues or for designing measures to prevent doxorubicin-induced cardiomyopathy.
This paper references
10.1126/SCIENCE.877547
Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response.
C. Myers (1977)
QRS voltage change with adriamycin administration.
R. A. Minow (1978)
Phase I clinical study of quelamycin.
A. Brugarolas (1978)
10.1002/1097-0142(197511)36:5<1577::AID-CNCR2820360507>3.0.CO;2-B
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin‐D and mithramycin
J. Kushner (1975)
A phase I II study of rubidazone in patients with solid tumors
R. Benjamin (1977)
Systolic time intervals in monitoring for anthracycline cardiomyopathy in pediatric patients.
R. Hutchinson (1978)
Time- and dose-dependent changes in ejection fraction determined by radionuclide angiography after anthracycline therapy.
J. Singer (1978)
Age-related adriamycin cardiotoxicity in children.
C. Pratt (1978)
10.1016/0002-9343(77)90315-1
Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases.
D. V. Von Hoff (1977)
A new antitumor antibiotic, carminomycin (NSC-180024).
Gause Gf (1974)
10.7326/0003-4819-81-4-475
Adriamycin cardiotoxicity in man.
J. Rinehart (1974)
10.1002/1097-0142(197307)32:1<9::AID-CNCR2820320102>3.0.CO;2-6
Adriamycin—an antitumor antibiotic in the treatment of neoplastic diseases
C. Tan (1973)
10.1002/1097-0142(197701)39:1<62::AID-CNCR2820390112>3.0.CO;2-J
Adriamycin cardiotoxicity in children. Case reports, literature review, and risk factors
M. Prout (1977)
10.7326/0003-4819-80-2-249
Adriamycin. A new anticancer drug with significant clinical activity.
R. Blum (1974)
10.1002/1097-0142(197401)33:1<19::AID-CNCR2820330107>3.0.CO;2-M
Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high‐dosage schedule
R. Benjamin (1974)
Adriamycin (NSC 123127) cardiomyopathy. An overview with determination of risk factors
R. A. Minow (1975)
10.2105/AJPH.47.4_PT_2.4
Measuring the Risk of Coronary Heart Disease in Adult Population Groups: II. Coronary Heart Disease in the Framingham Study
Thomas R. Dawber (1957)
10.1002/JSO.2930060607
Evaluation of cardiac function during adriamycin therapy
J. Burg (1974)
Noninvasive cardiac evaluation of patients receiving adriamycin.
G. Ewy (1978)
10.1002/1097-0142(197704)39:4<1397::AID-CNCR2820390407>3.0.CO;2-U
Adriamycin cardiomyopathy—risk factors
R. A. Minow (1977)
10.2307/1402659
Analysis of Survival Data under the Proportional Hazards Model
N. Breslow (1975)
10.1097/00000478-197701010-00002
Adriamycin cardiotoxicity: Endomyocardial biopsy evidence of enhancement by irradiation
M. Billingham (1977)
High incidence of cardiomyopathy in children treated with adriamycin and DTIC in combination chemotherapy.
P. Smith (1977)
10.1007/978-1-4612-4380-9_25
Nonparametric Estimation from Incomplete Observations
E. L. Kaplan (1958)
Time relationship between last dose of daunorubicin and congestive heart failure.
F. Cavalli (1977)
10.1002/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L
The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma
D. Karnofsky (1948)
10.1056/NEJM197902083000603
Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography.
J. Alexander (1979)
10.7326/0003-4819-82-1-122_2
Adriamycin and radiation: synegistic cardiotoxicity.
J. Merrill (1975)
Anthracycline cardiomyopathy monitored by morphologic changes.
M. Billingham (1978)
Systolic time intervals in monitoring adriamycin-induced cardiotoxicity.
S. Balcerzak (1978)
Subclinical adriamycin cardiotoxicity: detection by timing the arterial sounds.
G. Fa (1978)
10.1002/1097-0142(197307)32:1<1::AID-CNCR2820320101>3.0.CO;2-X
Phase II evaluation of adriamycin in human neoplasia
R. O'bryan (1973)
10.7326/0003-4819-88-2-168
Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyocardial biopsy, and cardiac catheterization.
M. Bristow (1978)
10.1136/bmj.1.6106.176-c
Doxorubicin cardiotoxicity: role of digoxin in prevention.
C. Williams (1978)
10.2307/2529620
Covariance analysis of censored survival data.
N. Breslow (1974)
A phase I II study of adriamycin DNA complex (A DNA)
R. Benjamin (1977)
10.1002/1097-0142(197804)41:4<1265::AID-CNCR2820410408>3.0.CO;2-R
Echocardiography in adriamycin cardiotoxicity
K. R. Bloom (1978)
Studies on adriamycin using a weekly regimen demonstrating its clinical effectiveness and lack of cardiac toxicity.
A. Weiss (1976)
Adriamycin and mitomycin C: possible synergistic cardiotoxicity.
A. Buzdar (1978)
Echocardiographic evaluation of adriamycin cardiotoxicity in children.
A. Ramos (1976)
10.1002/1097-0142(197308)32:2<302::AID-CNCR2820320205>3.0.CO;2-2
A clinicopathologic analysis of adriamycin cardiotoxicity
E. Lefrak (1973)



This paper is referenced by
10.5923/J.IJTT.20120102.01
Amelioration of Doxorubicin Induced Cardiotoxicity in Tumor Bearing Mice by Ferulic Acid: a Mechanistic Study at Cellular and Biochemical Level
Saratchandran A. Divakaran (2012)
Review Article Cardiomyopathy Associated With Cancer Therapy
Anthony F. Yu (2014)
10.1016/B978-0-12-802509-3.00003-0
Classification by Mechanisms of Cardiotoxicity
Dwight Kerkhove (2017)
10.11648/J.IJCOCR.20170202.12
Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products
Hayder M. Al-kuraishy (2017)
Prevalence Of Anthracycline Induced Cardiomyopathy Amongst Cancer Patients Treated At Kenyatta National Hospital
Caroline N Tonio (2018)
10.1152/ajpheart.00068.2009
Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.
P. Spallarossa (2009)
10.1200/JCO.1999.17.10.3333
American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants.
M. Hensley (1999)
10.1002/cncr.10946
A Phase II trial of pegylated liposomal doxorubicin, vincristine, and reduced‐dose dexamethasone combination therapy in newly diagnosed multiple myeloma patients
M. Hussein (2002)
10.1002/cncr.20207
Cardiac profiles of liposomal anthracyclines
M. Theodoulou (2004)
26 Drug-Induced Cardiomyopathies
J. Klimas (2012)
10.1016/j.lfs.2020.118216
Disruption of endothelial cell intraflagellar transport protein 88 exacerbates doxorubicin-induced cardiotoxicity.
Vincent Z Luu (2020)
10.1097/CAD.0000000000000326
Long-term response to first-line trabectedin in an elderly female patient with a metastatic leiomyosarcoma unfit for anthracycline
M. Maruzzo (2016)
A study of assessing cardiotoxicity by MUGA technique in patients treated for carcinoma breast
Bukya Sheela (2016)
10.1007/s10557-020-06941-x
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity
K. N. Timm (2020)
10.1016/j.biopha.2017.04.033
Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity.
A. Abushouk (2017)
10.1016/B978-0-12-803547-4.00021-5
Heart Transplantation and Left Ventricular Assist Devices in Cancer Survivors
E. Kransdorf (2017)
10.1007/978-3-540-75863-1_12
Heart, Coronary Arteries, Aorta and Great Vessels, Arteries and Veins, Microcirculation
B. Aleman (2014)
10.1016/B978-0-444-53856-7.00007-5
Chapter 7 – Cardiovascular System
P. Greaves (2012)
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
S. Ivanov (2013)
Natural Product Research: Formerly Natural Product Letters
F. Giampieri (2014)
10.1007/s10549-016-3678-2
Cardiac function in BRCA1/2 mutation carriers with history of breast cancer treated with anthracyclines
A. Barac (2016)
Cardiotoxicity after Adjuvant Anthracycline-based Chemotherapy and Radiotherapy for Breast Cancer
T. Yau (2005)
10.1016/S0378-5173(02)00075-3
Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome.
Y. Sadzuka (2002)
10.1054/EBON.2002.0022
Liposome-encapsulated doxorubicin is less cardiotoxic than conventional doxorubicin for metastatic breast cancer
C. Shapiro (2002)
10.1080/1042819021000006439
Concomitant Impairment of Left Ventricular Systolic and Diastolic Function During Doxorubicin Therapy: A Prospective Radionuclide Ventriculographic and Echocardiographic Study
T. Nousiainen (2002)
10.1007/s00432-008-0372-8
Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy
F. J. F. Broeyer (2008)
10.1200/JCO.2008.20.5013
Pegylated liposomal doxorubicin plus docetaxel significantly improves time to progression without additive cardiotoxicity compared with docetaxel monotherapy in patients with advanced breast cancer previously treated with neoadjuvant-adjuvant anthracycline therapy: results from a randomized phase II
J. Sparano (2009)
10.3816/CLM.2008.N.001
Clinical pharmacology of liposomal anthracyclines: focus on pegylated liposomal Doxorubicin.
R. Soloman (2008)
10.1016/J.JACC.2007.06.037
Early breast cancer therapy and cardiovascular injury.
L. Jones (2007)
10.1158/1078-0432.CCR-03-0644
A Phase I Trial of a Potent P-Glycoprotein Inhibitor, Zosuquidar Trihydrochloride (LY335979), Administered Intravenously in Combination with Doxorubicin in Patients with Advanced Malignancy
A. Sandler (2004)
10.1515/hsz-2016-0316
The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction
V. Dolinsky (2017)
10.1067/MHJ.2000.108237
Lack of clinically significant cardiac dysfunction during intermediate dobutamine doses in long-term childhood cancer survivors exposed to anthracyclines.
L. Lanzarini (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar